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Coli topoisomerase I. : 154361-50-9; 158798-73-3 266 Neuropathies associated with paraproteinemias Genetic testing NCVEMG Laboratory Imaging Biopsy Bone Type of paraproteinemia Multiple Myeloma MGUS (monoclonal gammopathy of undetermined significance) MGUS MAG POEMS Syndrome Waldenstroms macroglobulinemia Optiohs (AL type) Type of polyneuropathy Different types of polyneuropathy Amyloidosis may develop Sensorimotor or CIDP like Distal involvement, predominantly large fibers with ataxia and pseudoathetoid movements CIDP like Distal sensorimotor neuropathy, predilection for large fibers Polyneuropathy: autonomic involvement, involvement of skeletal muscle Treatment Treatment of myeloma Immunosuppression, various therapies are described Little beneficial effect of therapy Treatment of the myeloma, plasma- pheresis Treatment of Waldenstroms Colchicine, steroids Neuropathy in conjunction with multiple myeloma Anatomydistribution Symptoms Clinical syndrome signs Diagnosis Axonal neuropathy occurs with amyloid deposits.

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