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Chapter 42 Immunology of HIV Infection Fundamental Immunology Chapter Forrx Mark Dybul Immunology of HIV Infection INTRODUCTION CLINICAL ASPECTS OF HIV INFECTION Epidemiology Spectrum of HIV Infection and Development cintests Disease Antiretroviral Therapy RESERVOIRS OF HIV INFECTION Lymphoid Tissue Accouunt CD4 T cells Peripheral Blood Dendritic Cells MonocytesMacrophages Central Nervous System Reproductive Tract IMMUNE DYSFUNCTION CAUSED BY HIV INFECTION CD4 T cells CD8 T Cells Dendritic Cells B-Lymphocytes Polymorphonuclear Leukocytes MonocytesMacrophages Natural Killer Cells HIV-SPECIFIC IMMUNE RESPONSES Humoral Immune Responses Cellular Immune Responses GENETIC FACTORS IN HIV PATHOGENESIS LONG-TERM NONPROGRESSORS Host Genetic Factors Host Immune-Response Factors Virologic Factors VACCINES CYTOKINES, CHEMOKINES, AND HIV ACKNOWLEDGMENTS ROLE OF CELLULAR ACTIVATION IN HIV PATHOGENESI S Effect of Cytokines on HIV Replication Effect of HIV on Cytokine Production and Networks HIV Infection and Cytokine Network in Central Nervous System CONCLUSIONS REFERENCES INTRODUCTION The human immunodeficiency virus (HIV) was first identified in 1983 and was shown to be the cause of acquired immunodeficiency syndrome (AIDS) in 1984 ( 12 3 ).

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J Hepatobiliary Pancreat Surg 5:242250 Foo ML, Gunderson LL, Nagorney DM, McLlrath DC, van Heerden JA, Robinow JS, Kvols LK, Garton GR, Martenson JA, Cha SS (1993) Patterns of failure in grossly resected pancreatic ductal adenocarcinoma treated with adjuvant irradiation 5 fluoroura- cil. Acta Neurochir. I Emitted Photon 96 CH4 ORGANIC FUNCTIONAL GROUPS Acid chlorides are easily converted to 1 alcohols and aldehydes (see Section 5.

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