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and Burchell B. Lane, S. 116) in the ξηζ system. (2003). The latter has helped identify a number of areas of loss of heterozy- gosity (LOH), including 3p, 4q, 5q21-22, 8p21-23, 9p21-22, llq13, 11q23, 13q, 14q, 17p, 18q, and 22q [8-21], thus suggesting the contribution of several known tumor suppres- sor genes in HNSCC, such as p16 (9p21), APC (5q21-22), and p53 (17p13), as well as the existence of many novel putative tumor suppressor genes affected in HNSCC [22,23].et al.

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