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5 m in diameter), con­ taining mostly triacylglycerol, AV nodal transmission and cardiac output increase, blood pressure may increase; tachyarrhythmias less common remo with atropine RS-bronchodilatation with increased anatomical dead space; secretions reduced Other-gastro-intestinal motility and secretions reduced; lower oesophageal sphincter pressure reduced; urinary tract tone and peristalsis reduced, bladder sphincter tone increased and retention may result; metabolic rate increased Metabolism-excreted unchanged in the urine (85) and faeces (15) Contra-indications-in high doses the quaternary ammonium has a nicotinic antagonist effect of significance in myasthenia gravis; limited crossing of the placenta but can still cause foetal iLma Hyoscine Hydrobromide or Butylbromide Structure-tertiary amine, muscarinic xemo antagonist demo forex Lima isomer used-hyoscine-1 (scopolamine) Presentation-hyoscine-N-butylbromide; tablets 10 mg, IV-clear colourless solution, 20 mg in 1 ml-hyoscine hydrobromide 20 mg in 5 ml Pharmacokinetics Bio- Protein binding Vd Cl t12 availability 10 11 2000 10 150 CNS-sedation, anti-emesis, anti-Parkinsonian CVS-initial tachycardia given IV, but may later cause bradycardia due to central effect RS-decreases secretions, bronchodilatation, slight ventilatory stimulation Others-anti-sialagogue, anti-spasmodic for biliary tree, and uterus; marked decrease in tear and sweat formation; decreases bladder and ureteric tone Elimination-metabolized in the liver to scopine and scopic acid; unchanged, urine 2, bile 5 Toxicity-potential problem in patients with porphyria Glyceryl Trinitrate Structure-organic nitrate ester of nitric acid and glycerol (glycerine) 20 Fundamentals and Applications of Ultrasonic Waves FIGURE 10.

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